Journal article
Reduced microvascular density in non-ischemic myocardium of patients with recent non-ST-segment-elevation myocardial infarction
DJ Campbell, JB Somaratne, AJ Jenkins, DL Prior, M Yii, JF Kenny, AE Newcomb, DJ Kelly, MJ Black
International Journal of Cardiology | Published : 2013
Abstract
Background: Myocardial microvascular dysfunction has been implicated in the pathogenesis of myocardial infarction (MI). We tested the hypothesis that patients with MI have lower microvasculature density in myocardium remote from the site of infarction than patients with similar extent of coronary artery disease (CAD) without MI and examined the relationship between myocardial capillary length density and plasma levels of angiogenesis-related biomarkers. Methods: We analyzed biopsies from non-ischemic left ventricular (LV) myocardium and measured plasma levels of angiogenesis-related biomarkers in patients undergoing coronary artery bypass graft surgery, 57 without previous MI (no-MI) and 27 ..
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Grants
Awarded by National Health and Medical Research Council
Funding Acknowledgements
This work was funded by grants from the National Health and Medical Research Council of Australia and from the National Heart Foundation of Australia. D.J.C. (Grant ID 395508) and D.J.K. (Grant ID 566867) are recipients of Senior Research Fellowships from the National Health and Medical Research Council of Australia. St Vincent's Institute of Medical Research is supported in part by the Victorian Government's Operational Infrastructure Support Program.